Prof. Dr. med. Michael Wiesener
Oberarzt, Facharzt für Innere Medizin und Nephrologie, Zusatzbezeichnung Transplantationsmedizin, Hypertensiologe (DHL)
Lebenslauf, Veröffentlichungen und Auszeichnungen
Publikationen
- (2022) The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression. J Biol Chem. 2022;298(3):
- (2022) Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss. Bone Res. 2022;10(1):
- (2022) Diverse molecular causes of unsolved autosomal dominant tubulointerstitial kidney diseases. Kidney Int. 2022;102(2): 405-420
- (2022) Noninvasive Diagnosis of Acute Rejection in Renal Transplant Patients Using Mass Spectrometric Analysis of Urine Samples: A Multicenter Diagnostic Phase III Trial. Transplant Direct. 2022;8(5):
- (2022) Detecting tandem repeat variants in coding regions using code-adVNTR. iScience. 2022;25(8):
- (2022) An intermediate-effect size variant in UMOD confers risk for chronic kidney disease. Proc Natl Acad Sci U S A. 2022;119(33):
- (2022) Prevalence of hereditary tubulointerstitial kidney diseases in the German Chronic Kidney Disease study. Eur J Hum Genet. 2022;30(12): 1413-1422
- (2022) Correlation of Anti-HLA IgA Alloantibodies and Fc Receptor Motives with Kidney Allograft Survival Immuno. 2022;2(2): 372-386
- (2022) Monitoring complement biomarkers in C3 glomerulopathy patients with factor H or FHR gene mutations before and after treatment with eculizumab or ravulizumab Mol Immunol. 2022;141(): 201-201
- (2022) Biallelic ANKS6 mutations cause late-onset ciliopathy with chronic kidney disease through YAP dysregulation. Hum Mol Genet. 2022;31(9): 1357-1369
- (2021) BKPYV-SPECIFIC T CELLS REDUCE VIRAL LOAD IN A PRIMARY TUBULAR CELL MODEL Transpl Int. 2021;34 Suppl 2(): 23-24
- (2021) A noninvasive diagnostic approach to retrospective donor HLA typing in kidney transplant patients using urine. Transpl Int. 2021;34(7): 1226-1238
- (2021) PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Science. 2021;374(6573):
- (2020) A NEW DIAGNOSTIC APPROACH TO HLA TESTING IN KIDNEY TRANSPLANT RECIPIENTS USING CULTURED URINE DERIVED TUBULAR CELLS HLA. 2020;95(4): 313-313
- (2020) A New Diagnostic Approach to HLA Testing in Kidney Transplant Patients Using Renal Epithelial Cells Am J Transplant. 2020;20 Suppl 3(): 704-705
- (2020) Molecular diagnosis of kidney transplant failure based on urine. Am J Transplant. 2020;20(5): 1410-1416
- (2020) cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA. Genome Med. 2020;12(1):
- (2020) Kidney-transplant patients receiving living- or dead-donor organs have similar psychological outcomes (findings from the PI-KT study). Ment Illn. 2020;12(1): 17-22
- (2019) Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura. N Engl J Med. 2019;380(4): 335-346
- (2019) Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report. Medicine (Baltimore). 2019;98(36):
- (2019) Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction. PLoS Genet. 2019;15(4):
- (2019) Tuberculous granulomatous interstitial nephritis in a renal allograft. Kidney Int. 2019;96(5):
- (2019) Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disability BMC Cancer. 2019;19():
- (2019) Prenatal diagnosis of HNF1B-associated renal cysts: Is there a need to differentiate intragenic variants from 17q12 microdeletion syndrome? Prenat Diagn. 2019;39(12): 1136-1147
- (2019) An open-label, randomized trial indicates that everolimus with tacrolimus or cyclosporine is comparable to standard immunosuppression in de novo kidney transplant patients. Kidney Int. 2019;96(1): 231-244
- (2018) FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces. J Immunol. 2018;200(7): 2280-2290
- (2018) Single molecule real time sequencing in ADTKD-MUC1 allows complete assembly of the VNTR and exact positioning of causative mutations. Sci Rep. 2018;8(1):
- (2018) Hypoxia-inducible factor-1? is a critical transcription factor for IL-10-producing B cells in autoimmune disease. Nat Commun. 2018;9(1): 251
- (2018) Is Early Complement Activation in Renal Transplantation Associated with Later Graft Outcome? Kidney Blood Press Res. 2018;43(5): 1488-1504
- (2018) Biallelic Expression of Mucin-1 in Autosomal Dominant Tubulointerstitial Kidney Disease: Implications for Nongenetic Disease Recognition. J Am Soc Nephrol. 2018;29(9): 2298-2309
- (2017) Monitoring of complement activation biomarkers and eculizumab in complement-mediated renal disorders. Clin Exp Immunol. 2017;187(2): 304-315
- (2017) Mutations in mitochondrial DNA causing tubulointerstitial kidney disease. PLoS Genet. 2017;13(3): e1006620
- (2017) Induction therapy with rabbit antithymocyte globulin versus basiliximab after kidney transplantation: a health economic analysis from a German perspective. Transpl Int. 2017;30(10): 1011-1019
- (2017) HIF is not essential for suppression of experimental tumor growth by mTOR inhibition. J Cancer. 2017;8(10): 1809-1817
- (2016) Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol. 2016;27(5): 1413-25
- (2016) Experience with belatacept rescue therapy in kidney transplant recipients. Transpl Int. 2016;29(11): 1184-1195
- (2016) Rabbit-ATG or basiliximab induction for rapid steroid withdrawal after renal transplantation (Harmony): an open-label, multicentre, randomised controlled trial. Lancet. 2016;388(10063): 3006-3016
- (2015) Identification of Cyclin D1 and OtherNovel Targets for the von Hippel-Lindau Tumor Suppressor Gene by Expression Array Analysis and Investigation of Cyclin D1 Genotype as a Modifier in von Hippel-Lindau Disease (vol 62, pg 3803, 2002) Cancer Res. 2015;75(18): 3993-3993
- (2015) Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management-A KDIGO consensus report. Kidney Int. 2015;88(4): 676-83
- (2015) The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus. Ann Rheum Dis. 2015;74(7): 1474-8
- (2015) Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1) Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis. Kidney Blood Press Res. 2015;40(5): 443-51
- (2015) Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis. Kidney Int. 2015;88(6): 1283-1292
- (2015) Depression, Anxiety, Resilience and Coping Pre and Post Kidney Transplantation - Initial Findings from the Psychiatric Impairments in Kidney Transplantation (PI-KT)-Study. PLoS ONE. 2015;10(11): e0140706
- (2015) Association of a coding polymorphism in Fc gamma receptor 2A and graft survival in re-transplant candidates. Hum Immunol. 2015;76(10): 759-64
- (2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest. 2014;124(1): 145-55
- (2014) Renal fibrosis is the common feature of autosomal dominant tubulointerstitial kidney diseases caused by mutations in mucin 1 or uromodulin. Kidney Int. 2014;86(3): 589-99
- (2014) Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro. Mol Carcinog. 2014;53(12): 970-8
- (2013) Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule. Am J Physiol Renal Physiol. 2013;305(5): F734-44
- (2012) Renal Tubular HIF-2? Expression Requires VHL Inactivation and Causes Fibrosis and Cysts. PLoS ONE. 2012;7(1): e31034
- (2011) The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia. BBA - MOL CELL RES. 2011;1813(1): 1-13
- (2011) Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. J Am Soc Nephrol. 2011;22(11): 2004-15
- (2010) The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem. 2010;285(9): 6658-69
- (2010) Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010;24(11): 4443-58
- (2010) Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol. 2010;21(12): 2151-6
- (2009) Mutual regulation of hypoxia-inducible factor and mammalian target of rapamycin as a function of oxygen availability. Mol Cancer Res. 2009;7(1): 88-98
- (2009) Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol Cell Biol. 2009;29(7): 1707-18
- (2009) HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia. Cell Cycle. 2009;8(9): 1386-95
- (2009) HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol. 2009;174(5): 1663-74
- (2009) Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines. Nephrol Dial Transplant. 2009;24(11): 3319-25
- (2009) Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression. J Mol Med. 2009;87(9): 871-7
- (2009) The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem J. 2009;424(1): 143-51
- (2009) Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A. 2009;106(50): 21276-81
- (2009) Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma. Anticancer Res. 2009;29(11): 4337-43
- (2008) HIF activation protects from acute kidney injury. J Am Soc Nephrol. 2008;19(3): 486-94
- (2008) Hypoxia and Hypoxia-Inducible Factor-1{alpha} Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function. J Immunol. 2008;180(7): 4697-705
- (2008) The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp Cell Res. 2008;314(10): 2016-27
- (2008) Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 2008;133(2): 223-34
- (2008) Chondrogenic differentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1alpha activity. Osteoarthritis Cartilage. 2008;16(12): 1457-65
- (2008) Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. Arthritis Res Ther. 2008;10(5): R111
- (2008) Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction. Biochem J. 2008;409(1): 233-42
- (2007) Identification of novel VHL targets that are associated with the development of renal cell carcinoma. Oncogene. 2007;26(11): 1661-72
- (2007) Characterization of a 3;6 translocation associated with renal cell carcinoma. Genes Chromosomes Cancer. 2007;46(4): 311-7
- (2007) Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am J Pathol. 2007;170(3): 830-42
- (2007) Hypoxia-inducible transcription factors and their role in renal disease. Semin Nephrol. 2007;27(3): 363-72
- (2007) Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia. Int J Cancer. 2007;121(11): 2434-42
- (2007) The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol. 2007;171(5): 1483-98
- (2007) Organ protection by hypoxia and hypoxia-inducible factors. Methods Enzymol. 2007;435(): 219-45
- (2006) Inconsistent effects of acidosis on HIF-alpha protein and its target genes. Pflugers Arch. 2006;451(4): 534-43
- (2006) Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys. Kidney Int. 2006;70(1): 60-70
- (2006) Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol. 2006;17(7): 1970-8
- (2006) HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. J Mol Cell Cardiol. 2006;41(1): 68-77
- (2006) Expression of hypoxia-inducible transcription factors in developing human and rat kidneys. Kidney Int. 2006;69(1): 114-22
- (2005) Role of hypoxia in the pathogenesis of renal disease Kidney Int. 2005;68 Suppl. (): 46-51
- (2005) Role of hypoxia in the pathogenesis of renal disease. Kidney Int Suppl. 2005;(99): S46-51
- (2005) Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma. Cancer Res. 2005;65(11): 4598-606
- (2005) Inhibition of mTOR attenuates hypoxic gene regulation in renal cells Nephrol Dial Transplant. 2005;20 Suppl.(): V16-V17
- (2005) Preconditional induction of HIF by carbon monoxide ameliorates ischemic acute renal failure Nephrol Dial Transplant. 2005;20 Suppl.(): V54-V54
- (2004) Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J. 2004;18(12): 1462-4
- (2004) Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. FASEB J. 2004;18(12): 1415-7
- (2003) Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J. 2003;17(2): 271-3
- (2003) Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. FASEB J. 2003;17(9): 1186-8
- (2003) Role of hypoxia in the pathogenesis of renal disease. Blood Purif. 2003;21(3): 253-7
- (2003) Cellular responses to hypoxia after renal segmental infarction. Kidney Int. 2003;64(3): 874-86
- (2002) Erythropoietin, tumours and the von Hippel-Lindau gene: towards identification of mechanisms and dysfunction of oxygen sensing. Nephrol Dial Transplant. 2002;17(3): 356-9
- (2002) Paraneoplastic erythrocytosis associated with an inactivating point mutation of the von Hippel-Lindau gene in a renal cell carcinoma. Blood. 2002;99(10): 3562-5
- (2002) Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol. 2002;13(7): 1721-32
- (2002) Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease. Cancer Res. 2002;62(13): 3803-11
- (2001) Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res. 2001;61(13): 5215-22
Sprechstunden
Nierenerkrankungen (genetisch)
Sprechstunde für genetische Nierenerkrankungen unklarer Genese
Spezialsprechstunde
Prof. Dr. med. Michael Wiesener
Prof. Dr. med. Michael Wiesener
Zeiten
nach Vereinbarung
Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen
Raum
D 0 723-1
Terminvergabe nur nach Absprache
Hochschulambulanz
Montag bis Freitag
11.00 - 15.00 Uhr
Telefon: 09131 85-32566
Fax: 09131 85-33431
Hinweis
Bei dieser Sprechstunde steht die Diagnostik im Vordergrund.
Mitzubringen
- Versicherungsnachweis (Krankenkassenkarte)
- Zuweisung
- Medikamentenliste
- Befundberichte von Ihrem Facharzt (falls vorhanden)
Nierentransplantationsnachsorge
Spezialsprechstunde
Prof. Dr. med. Michael Wiesener
Prof. Dr. med. Michael Wiesener
Dr. med. Mirian Opgenoorth
Zeiten
nach Vereinbarung
Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen
Raum
D 0 723-1
Terminvergabe nur nach Absprache
Hochschulambulanz
Montag bis Freitag
11.00 - 15.00 Uhr
Telefon: 09131 85-32566
Fax: 09131 85-33431
Hinweis
Patienten nach erfolgter Nierentransplantation werden in dieser Sprechstunde umfassend betreut. Dabei kümmern wir uns auch intensiv um Immunsuppression und die Transplantatfunktion.
Mitzubringen
- Versicherungsnachweis (Krankenkassenkarte)
- Zuweisung
- Medikamentenliste
- Befundberichte von Ihrem Facharzt (falls vorhanden)
Allgemeinsprechstunde
Nephrologie
Dr. med. Kristina Rodionova
Prof. Dr. med. Michael Wiesener
Prof. Dr. med. Michael Wiesener
Dr. med. Anne Dieterle
PD. Dr. med. Kristina Rodionova
Zeiten
nach Vereinbarung
Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen
Raum
D 0 723-1
Terminvergabe nur nach Absprache
Hochschulambulanz
Montag bis Freitag
11.00 - 15.00 Uhr
Telefon: 09131 85-32566
Fax: 09131 85-33431
Hinweis
In dieser Sprechstunde werden Patienten mit komplexer und schwerwiegender chronischer Niereninsuffizienz betreut in Zusammenarbeit mit den niedergelassenen Nephrologen.
Mitzubringen
- Versicherungsnachweis (Krankenkassenkarte)
- Zuweisung
- Medikamentenliste
- Befundberichte von Ihrem Facharzt (falls vorhanden)
Pankreastransplantationsnachsorge
Bauchspeicheldrüse
Spezialsprechstunde
Prof. Dr. med. Michael Wiesener
Prof. Dr. med. Michael Wiesener
Dr. med. Mirian Opgenoorth
Zeiten
Montag - Freitag: ab 7.30 Uhr
Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen
Raum
D 0 723-1
Terminvergabe nur nach Absprache
Hochschulambulanz
Montag bis Freitag
11.00 - 15.00 Uhr
Telefon: 09131 85-32566
Fax: 09131 85-33431
Hinweis
Patienten nach erfolgter kombinierter Pankreas-Nierentransplantation werden in dieser Sprechstunde umfassend betreut. Dabei kümmern wir uns auch intensiv um Immunsuppression und die Transplantatfunktion.
Mitzubringen
- Versicherungsnachweis (Krankenkassenkarte)
- Zuweisung
- Medikamentenliste
- Befundberichte von Ihrem Facharzt (falls vorhanden)