Prof. Dr. med. Karl F. Hilgers
Stellvertretender Direktor, Facharzt für Innere Medizin, Hypertensiologe (DHL)
Lebenslauf, Veröffentlichungen und Auszeichnungen
Publikationen
- (2022) Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. Sci Rep. 2022;12(1):
- (2022) Empagliflozin Improves Impaired Sensitivity Of Afferent Neurons With Renal Axons Hypertension. 2022;79 Suppl 1():
- (2022) High Sodium Intake Effects On Afferent Renal Nerve Activity Hypertension. 2022;79 Suppl 1():
- (2022) Vitamin K1 and progression of cardiovascular calcifications in hemodialysis patients: the VitaVasK randomized controlled trial Clin Kidney J. 2022;15(12): 2300-2311
- (2021) Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure. Acta Physiol (Oxf). 2021;232(1):
- (2021) RNA sequencing reveals induction of specific renal inflammatory pathways in a rat model of malignant hypertension. J Mol Med. 2021;99(12): 1727-1740
- (2021) AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? Kidney Blood Press Res. 2021;46(3): 331-341
- (2021) Responsiveness of afferent renal nerve units in renovascular hypertension in rats. Pflugers Arch. 2021;473(10): 1617-1629
- (2021) Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury. Physiol Genomics. 2021;53(12): 509-517
- (2021) Neurogenic substance P-influences on action potential production in afferent neurons of the kidney? Pflugers Arch. 2021;473(4): 633-646
- (2020) Neurogenic tachykinin mechanisms in experimental nephritis of rats. Pflugers Arch. 2020;472(12): 1705-1717
- (2020) Afferent renal innervation in anti-Thy1.1 nephritis in rats. Am J Physiol Renal Physiol. 2020;319(5): F822-F832
- (2020) Correlations Between Interleukin-11 Expression and Hypertensive Kidney Injury in a Rat Model of Renovascular Hypertension. Am J Hypertens. 2020;33(4): 331-340
- (2020) A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney. Mol Cell Pediatr. 2020;7(1):
- (2020) After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy. Kidney Int. 2020;98(4): 1044-1052
- (2019) Association of donor hypertension and recipient renal function in living donor kidney transplantation: A single-center retrospective study. Clin Transplant. 2019;33(10):
- (2019) Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report. Medicine (Baltimore). 2019;98(36):
- (2019) Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens. Microcirculation. 2019;26(3):
- (2019) Renal Chemerin Expression is Induced in Models of Hypertensive Nephropathy and Glomerulonephritis and Correlates with Markers of Inflammation and Fibrosis. Int J Mol Sci. 2019;20(24):
- (2019) Overexpression of Alanine-Glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function Circulation. 2019;140 Suppl 1():
- (2018) In-situ analysis of mast cells and dendritic cells in coronary atherosclerosis in chronic kidney disease (CKD). Histol Histopathol. 2018;33(8): 871-886
- (2018) Neonatal nephron loss during active nephrogenesis - detrimental impact with long-term renal consequences. Sci Rep. 2018;8(1):
- (2018) Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study. PLoS ONE. 2018;13(8): e0202604
- (2018) Correction: Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study. PLoS ONE. 2018;13(9):
- (2018) Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention. Kidney Blood Press Res. 2018;43(1): 1-11
- (2017) Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int. 2017;91(3): 616-627
- (2017) Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralocorticoid Receptor Antagonism? Hypertension. 2017;69(1): 11-12
- (2017) ADHERE: randomized controlled trial comparing renal function in de novo kidney transplant recipients receiving prolonged-release tacrolimus plus mycophenolate mofetil or sirolimus. Transpl Int. 2017;30(1): 83-95
- (2017) Vascular inflammation and media calcification are already present in early stages of chronic kidney disease. Cardiovasc Pathol. 2017;27(): 57-67
- (2017) Blunted transcriptional response to skeletal muscle ischemia in rats with chronic kidney disease: potential role for impaired ischemia-induced angiogenesis. Physiol Genomics. 2017;49(4): 230-237
- (2017) Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8. Biol Sex Differ. 2017;8(): 19
- (2017) Dosing of indocyanine green for intraoperative laser fluorescence angiography in kidney transplantation. Microcirculation. 2017;24(8):
- (2017) [How to Retard Progression of Chronic Kidney Disease]. Dtsch Med Wochenschr. 2017;142(17): 1282-1289
- (2017) Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies. Nephrol Dial Transplant. 2017;32(2): 325-332
- (2016) Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program (ESP): A Single-Center Experience from 2008 to 2013. Ann Transplant. 2016;21(): 94-104
- (2016) Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover. PLoS ONE. 2016;11(3): e0150471
- (2016) Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease - cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort. BMC Nephrol. 2016;17(1): 59
- (2016) Impaired Neovascularization and Reduced Capillary Supply in the Malignant vs. Non-malignant Course of Experimental Renovascular Hypertension. Front Physiol. 2016;7(): 370
- (2015) Under-expression of ?8 integrin aggravates experimental atherosclerosis. J Pathol. 2015;236(1): 5-16
- (2015) High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest. 2015;125(11): 4223-38
- (2015) Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med. 2015;373(23): 2225-36
- (2014) Darbepoetin alpha reduces oxidative stress and chronic inflammation in atherosclerotic lesions of apo e deficient mice in experimental renal failure. PLoS ONE. 2014;9(2): e88601
- (2014) Contribution of the ?8 integrin chain to the expression of extracellular matrix components. Cell Commun Adhes. 2014;21(2): 89-98
- (2014) What should be the goal blood pressure in nondiabetic chronic kidney disease? Curr Opin Nephrol Hypertens. 2014;23(2): 180-5
- (2014) Effect of lowering asymmetric dimethylarginine (ADMA) on vascular pathology in atherosclerotic ApoE-deficient mice with reduced renal mass. Int J Mol Sci. 2014;15(4): 5522-35
- (2014) Impaired myocardial performance in a normotensive rat model of intrauterine growth restriction. Pediatr Res. 2014;75(6): 697-706
- (2014) Donor acute kidney injury and short-term graft outcome in renal transplantation. Clin Transplant. 2014;28(10): 1131-41
- (2014) Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells. Cell Adh Migr. 2014;8(4): 389-95
- (2014) Renal protection by low dose irbesartan in diabetic nephropathy is paralleled by a reduction of inflammation, not of endoplasmic reticulum stress Biochim Biophys Acta Mol Basis Dis. 2014;1842(4): 558-565
- (2013) Reduced Firing Activity of Afferent Renal Innervation in the 2kidney/1clip Model of Hypertension Hypertension. 2013;62 S(3): -
- (2013) Circulating dendritic cell precursors in chronic kidney disease: a cross-sectional study. BMC Nephrol. 2013;14(): 274
- (2013) Intrauterine growth restriction leads to a dysregulation of Wilms' tumour supressor gene 1 (WT1) and to early podocyte alterations. Nephrol Dial Transplant. 2013;28(6): 1407-17
- (2013) Hypertension: Resistant hypertension matters in chronic kidney disease. Nat Rev Nephrol. 2013;9(8): 441-2
- (2013) BK viremia and polyomavirus nephropathy in 352 kidney transplants; risk factors and potential role of mTOR inhibition. BMC Nephrol. 2013;14(): 207
- (2013) Cardiovascular and Renal Effects of High Salt Diet in GDNF+/- Mice with Low Nephron Number. Kidney Blood Press Res. 2013;37(4-5): 379-91
- (2012) Intrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats. Clin Sci (Lond). 2012;123(7): 437-44
- (2012) An experimental procedure paid for by the general public. Dtsch Arztebl Int. 2012;109(17): 311-2; author reply 313-4
- (2012) Tubulointerstitial de novo expression of the ?8 integrin chain in a rodent model of renal fibrosis - a potential target for anti-fibrotic therapy? PLoS ONE. 2012;7(11): e48362
- (2012) The German Chronic Kidney Disease (GCKD) study: design and methods. Nephrol Dial Transplant. 2012;27(4): 1454-60
- (2012) From red to white urine: a patient's nightmare with a rather benign outcome. BMC Nephrol. 2012;13(): 7
- (2012) A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy. BMC Nephrol. 2012;13(): 27
- (2011) Early glomerular alterations in genetically determined low nephron number. Am J Physiol Renal Physiol. 2011;300(2): F521-30
- (2011) Sympathetic blockade prevents the decrease in cardiac VEGF expression and capillary supply in experimental renal failure. Am J Physiol Renal Physiol. 2011;300(1): F105-12
- (2011) High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy. PLoS ONE. 2011;6(1): e15287
- (2011) Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men. Pharmacogenet Genomics. 2011;21(6): 347-9
- (2011) Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction. PLoS ONE. 2011;6(5): e20369
- (2011) Effect of the plasminogen-plasmin system on hypertensive renal and cardiac damage. J Hypertens. 2011;29(8): 1602-12
- (2010) An unusual case of hyponatraemia. Nephrol Dial Transplant. 2010;25(3): 998-1001
- (2010) Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine. Am J Pathol. 2010;176(5): 2559-70
- (2010) Severe metabolic alkalosis and recurrent acute on chronic kidney injury in a patient with Crohn's disease. BMC Nephrol. 2010;11(): 6
- (2010) Images in vascular medicine: Renal arteriovenous fistula. Vasc Med. 2010;15(5): 433-4
- (2010) Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis. Nephron Exp Nephrol. 2010;115(3): e80-8
- (2010) Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy. Am J Physiol Renal Physiol. 2010;299(5): F1151-7
- (2010) Lack of ?8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells. BMC Cell Biol. 2010;11(): 102
- (2009) Deletion of the alpha8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension. Am J Hypertens. 2009;22(1): 92-9
- (2009) Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus. Am J Kidney Dis. 2009;53(2): 281-9
- (2009) Lack of nidogen-2 increases blood pressure, glomerular and tubulointerstitial damage in DOCA-salt hypertension. Eur J Clin Invest. 2009;39(2): 116-25
- (2009) Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension. J Hypertens. 2009;27(2): 376-85
- (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med. 2009;15(5): 545-52
- (2009) [In Process Citation] Urologe A. 2009;48(8): 925-33; quiz 934-5
- (2009) Developmental renin expression in mice with a defective renin-angiotensin system. Am J Physiol Renal Physiol. 2009;297(5): F1371-80
- (2009) C-reactive protein: more than just a marker of inflammation? J Hypertens. 2009;27(9): 1748-9
- (2009) New approaches to pathogenesis and management of hypertension. Clin J Am Soc Nephrol. 2009;4(12): 1886-91
- (2008) (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in goldblatt rats. Hypertension. 2008;51(3): 676-81
- (2008) A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. Nephron Clin Pract. 2008;108(3): c169-75
- (2008) [Chronic kidney disease and the cardiovascular system.] Internist (Berl). 2008;49(4): 413-21
- (2008) Acute syphilitic chorioretinitis after a missed primary diagnosis: a case report. J Med Case Reports. 2008;2(1): 33
- (2008) Autonomic renal denervation ameliorates experimental glomerulonephritis. J Am Soc Nephrol. 2008;19(7): 1371-8
- (2008) Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension. Nephrol Dial Transplant. 2008;23(11): 3456-63
- (2008) Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension. 2008;52(1): 123-9
- (2008) Transient receptor potential vanilloid type 1 receptors in hypertensive renal damage: a promising therapeutic target? Hypertension. 2008;52(2): 213-4
- (2008) The choice of antihypertensive therapy in patients with the metabolic syndrome--time to change recommendations? Nephrol Dial Transplant. 2008;23(11): 3389-91
- (2008) [The kidneys and the heart] Dtsch Med Wochenschr. 2008;133(37): 1839-43
- (2008) Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats. Am J Physiol Renal Physiol. 2008;295(6): F1752-63
- (2008) Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome. J Physiol. 2008;586(Pt 2): 459-75
- (2008) Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II. Kidney Int. 2008;73(5): 643-50
- (2008) Glomerular regeneration is delayed in nephritic alpha 8-integrin-deficient mice: contribution of alpha 8-integrin to the regulation of mesangial cell apoptosis. Am J Nephrol. 2008;28(1): 168-78
- (2008) Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice. Am J Physiol Heart Circ Physiol. 2008;294(2): H1058-66
- (2007) Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes. Am J Physiol Renal Physiol. 2007;292(2): F820-7
- (2007) Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats. Am J Physiol Renal Physiol. 2007;292(5): F1490-500
Sprechstunden
Bluthochdruck (schwer einstellbar)
Spezialsprechstunde
Prof. Dr. med. Karl F. Hilgers
Dr. med. Dennis Kannenkeril
Prof. Dr. med. Karl F. Hilgers
Zeiten
Montags ab 11 Uhr nur nach Vereinbarung
Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen
Raum
D 0 723-1
Terminvergabe nur nach Absprache
siehe "Hinweis"
Hinweis
In dieser Sprechstunde werden Patienten mit schwer einstellbarer arterieller Hypertonie und sekundären Formen der Hypertonie behandelt.
Für diese Sprechstunde ist eine vorherige Terminvereinbarung notwendig.
Wir bitten Sie, Ihren betreuenden Hausarzt oder Internisten, uns vorab folgende Unterlagen (soweit indiziert bzw. erhoben) per Fax (an 09131 85-33431) oder per Post zu schicken:
- Überweisungsschein vom Facharzt für Nephrologie
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- TSH basal
- Aldosteron, Renin
- Urin-Albumin/Kreatinin-Verhältnis
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Bitte denken Sie daran, Ihre Kontaktdaten bzw. die des Patienten anzugeben (Name, Adresse, Telefonnummer).
Diese Unterlagen werden dem zuständigen Oberarzt vorgelegt. Erst danach werden Sie zur Terminvereinbarung von uns angerufen oder angeschrieben.
Mitzubringen
- Versicherungsnachweis (Krankenkassenkarte)
Elektrolytstörungen
Spezialsprechstunde
Prof. Dr. med. Karl F. Hilgers
PD Dr. med. Christoph Kopp
Prof. Dr. med. Karl F. Hilgers
PD Dr. med. Christoph Kopp
Zeiten
nach Vereinbarung
Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen
Raum
D 0 723-1
Terminvergabe nur nach Absprache
Hochschulambulanz
Montag bis Freitag
11.00 - 15.00 Uhr
Telefon: 09131 85-32566
Fax: 09131 85-33431
Hinweis
Diese Sprechstunde richtet sich an Patienten mit seltenen Formen der Hypertonie und Elektrolytstörungen.
Mitzubringen
- Versicherungsnachweis (Krankenkassenkarte)
- Zuweisung
- Medikamentenliste
- Befundberichte von Ihrem Facharzt (falls vorhanden)